iLab can be tailored to match each institution's actual approval work flow for core services. This can include the participation of lab managers and financial administrators where appropriate. Core facility personnel update the status of active requests. Updates can include indicating when work has begun on a service, when work is completed, and when a service is ready for billing. For complex projects with multiple subcomponents, core facility personnel can update the status of particular subcomponents. In addition, the iLab system allows core facility managers to add new charges that arise during the course of an ongoing project. The iLab system automatically generates an audit trail of all approvals and charges made during the course of a project.

In addition to tracking billing-related information, the iLab system also supports scientific communication between cores and their customers. Core personnel and customers can share files or add comments confidentially.